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The Center of Applied Biosciences
(CAB) is an institution of the University of Freiburg (UNIFR), one of the
top ranked german universities (Nr. 3 in Germany and Nr. 6 by the European
Community). At the CAB research projects from 6 different faculties are
performed in the area of Nano-Biotechnology, Transgenic Technologies and Tissue
Engineering, Medical Technologies, Plant Biotechnology and Computational
Biology. Within this project the project team will perform various surface
functionalisations of Si NPs to modify their chemical-physical structures at the
biomolecular scale. Specific emphasis will be given to the question whether
RNA-mediated gene silencing can be introduced via Si NPs into cells. The team is
part of the excellently equipped Freiburg Life Image Center, which houses a set
of advanced microscopes including confocal laser scanning microscopy,
2-photon-microscopy, ultrarapid microscopy at confocal resolution, automated
microscopy for high-content screening of fixed or living biological samples. The
leader of the team is Prof Dr. Klaus Palme, who is an authority in the field of
bio-imaging. In this project Prof Palme's project team consists of 1 technician,
1 postdoctoral researcher contributed from internal resources and a postdoctoral
associate to be hired for the project. The team will closely collaborate with
the other project partners to implement the novel NPs into bioscreening
applications.
In this project Prof. Palme's activities rest on the continous availability of
Si NPs.
Some selected
publications:
Blilou, I., Wildwater, M., Willemsen, V., Papanov,
I., Friml, J., Heidstra, R., Palme, K.
Scheres, B.
The PIN auxin efflux
facilitator network controls patterning and cell
division
Nature 433,
39-44 (2005)
Geldner, N., Friml, J., Stierhof, S., Jürgens, G., Palme, K.
Reversible
regulation of polar insertion of AtPIN1
Nature
413, 425-428 (2001).
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